General Information

  • ID:  hor003033
  • Uniprot ID:  P34962
  • Protein name:  Neuromedin-U-25
  • Gene name:  nmu
  • Organism:  Canis lupus familiaris (Dog) (Canis familiaris)
  • Family:  NmU family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Canis lupus (species), Canis (genus), Canidae (family), Caniformia (suborder), Carnivora (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0006940 regulation of smooth muscle contraction; GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  FRLDEEFQGPIASQVRRQFLFRPRN
  • Length:  25(1-25)
  • Propeptide:  FRLDEEFQGPIASQVRRQFLFRPRN
  • Signal peptide:  NA
  • Modification:  T18 Pyrrolidone carboxylic acid;T25 Asparagine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates uterine smooth muscle contraction and causes selective vasoconstriction.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-O65684-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-O65684-F1.pdbhor003033_AF2.pdbhor003033_ESM.pdb

Physical Information

Mass: 353577 Formula: C140H216N44O37
Absent amino acids: CHKMTWY Common amino acids: R
pI: 11.9 Basic residues: 5
Polar residues: 3 Hydrophobic residues: 9
Hydrophobicity: -88.4 Boman Index: -9013
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 62.4
Instability Index: 6455.2 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  2052487
  • Title:  Isolation, Structural Characterization and Pharmacological Activity of Dog Neuromedin U